Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Mol Nutr Food Res. 2017 Aug 14;61(10):10.1002/mnfr.201700111. doi: 10.1002/mnfr.201700111

Table 1.

Pharmacokinetic Parameters of flavan-3-ol, quercetin and resveratrol metabolites of rats treated for 10 days.

		Parameters

	Treatment	AUC_0–8h (μmol/L^* h)	C_max (μmol/L)	T_max (h)
C-5-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	76.28 ± 16.74	18.54 ± 3.58	2.31 ± 0.53
	LN-SGP	93.36 ± 11.04	35.89 ± 4.65^*	1.50 ± 0.19^╪

EC-5-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	59.70 ± 13.53	15.51 ± 2.76	2.13 ± 0.44
	LN-SGP	81.20 ± 11.28	31.33 ± 4.28^*	1.56 ± 0.22

3′-OMeC-5-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	25.09 ± 13.47	5.37 ± 2.94	1.75 ± 0.16
	LN-SGP	108.09 ± 6.65^*	24.75 ± 1.62^*	1.75 ± 0.16

3′-OMeEC-5-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	22.95 ± 12.40	4.90 ± 2.62	2.00 ± 0.00
	LN-SGP	110.26 ± 5.94^*	24.06 ± 1.84^*	1.88 ± 0.13

Q-3-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	.028 ± .002	.008 ± .001	0.56 ± 0.14
	LN-SGP	.051 ± .007^*	.015 ± .002^*	1.25 ± 0.43

MeO-Q-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	.071 ± .003	.014 ± .006	2.50 ± 0.80
	LN-SGP	.123 ± .019^*	.028 ± .004^*	0.84 ± 0.19^*

Res-3-glucr	ZDF-CNTL	N.D.	N.D.	N.D.
	LN-CNTL	N.D.	N.D.	N.D.
	ZDF-SGP	180.78 ± 20.54	34.36 ± 3.48	2.63 ± 0.84
	LN-SGP	328.85 ± 40.53^*	60.36 ± 6.32^*	2.19 ± 0.92

^*

Significant difference from ZDF-SGP and LN-SGP groups. p < 0.05

^╪

difference between ZDF-SGP and LN-SGP groups 0.05 < p < 0.1