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. 2017 Aug;18(4):341–359. doi: 10.2174/1389202918666170307161643

Table 2.

The revised bethesda guidelines [11].

1) CRC diagnosed in a patient younger than 50 years
2) Presence of synchronous, metachronous colorectal or other HNPCC-associated tumours1 regardless of age
3) CRC with MSI-H2 histology diagnosed in a patient younger than 60 years
4) CRC diagnosed in at least one first-degree relative with a HNPCC-related cancer with one of the cancers being diagnosed before the age of 50 years.
5) CRC in at least two first- or second-degree relatives with HNPCC-related tumours regardless of age

1 Tumours in colon, rectum, endometrium, ventricle, ovaries, pancreas, ureter, renal pelvis, biliary tract, brain, jejunum and duodenum and sebaceous gland adenomas and keratoacanthomas in Muir-Torre syndrome. 2 MSI-H: microsatellite instability high grade.