Table 3.
Comparative distribution of genotype frequencies of gene polymorphisms associated with obesity, vascular/cardiovascular risk, and neurodegeneration in our study and other European populations [48, 49].
| __ | __ | Genotype Frequencies | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Genotypes | Our Study | N-W Europeans |
Western
Europeans |
Finnish | British | Spanish | Italian |
| A2M | AA AG GG | 0.482 0.425 0.093 | 0.465 0.446 0.089 |
0.625 0.250 0.125 |
0.333 0.465 0.202 | 0.428 0.495 0.077 |
0.551 0.402 0.047 |
0.504 0.421 0.075 |
| χ2 = 0.07 P>0.95 | χ2 = 7.13 P<0.05 | χ2 = 18.31 P<0.001 | χ2 = 0.97 P>0.65 | χ2 = 3.46 P>0.2 | χ2 = 0.44 P=0.8 | |||
| ACE | CC CT TT | 0.117 0.450 0.433 | -- | 0.149 0.474 0.376 |
0.152 0.515 0.333 | 0.263 0.473 0.264 | 0.178 0.486 0.336 |
0.121 0.43 0.449 |
| -- | χ2 = 5.78 P>0.05 | χ2 = 11.22 P<0.005 | χ2 = 16.43 P<0.001 | χ2 = 9.49 P<0.01 | χ2 = 3.29 P>0.15 | |||
| AGT-174 | GG GA AA | 0.762 0.222 0.016 | 0.791 0.200 0.009 |
0.783 0.217 0.000 |
0.627 0.343 0.030 | 0.791 0.209 0.000 | 0.803 0.178 0.019 |
0.757 0.215 0.028 |
| χ2 = 1.97 P>0.4 | χ2 = 1.08 P>0.55 | χ2 = 10.59 P=0.005 | χ2 = 2.07 P>0.35 | χ2 = 0.75 P>0.65 | χ2 = 0.19 P>0.9 | |||
| AGT-235 | AA AG GG | 0.254 0.500 0.246 | 0.371 0.434 0.195 |
0.218 0.652 0.130 |
0.303 0.535 0.162 | 0.384 0.484 0.132 |
0.355 0.439 0.206 | 0.365 0.439 0.196 |
| χ2 = 39.89 P<0.001 | χ2 = 1.21 P>0.5 | χ2 = 6.28 P<0.05 | χ2 = 18.5 P<0.001 | χ2 = 17.04 P<0.001 | χ2 = 18.55 P<0.001 | |||
| APOC3 | CC CG GG | 0.821 0.170 0.009 | 1.000 0.000 0.000 |
0.841 0.159 0.000 |
0.727 0.263 0.010 | 0.770 0.220 0.010 |
0.766 0.206 0.028 |
0.757 0.224 0.019 |
| χ2 = 46.00 P<0.001 | χ2 = 0.63 P>0.7 | χ2 = 6.43 P<0.05 | χ2 = 2.03 P>0.35 | χ2 = 3.05 P>0.2 | χ2 = 3.00 P>0.2 | |||
| IL1B | CC CT TT | 0.632 0.326 0.042 | 0.159 0.310 0.531 |
0.583 0.250 0.167 |
0.566 0.394 0.040 | 0.450 0.473 0.077 | 0.617 0.374 0.009 | 0.533 0.402 0.065 |
| χ2 = 359.5 P<0.001 | χ2 = 10.55 P<0.01 | χ2 = 3.61 P>0.15 | χ2 = 13.41 P<0.0025 | χ2 = 5.62 P>0.05 | χ2 = 5.15 P>0.05 | |||
| IL6-174 | GG GC CC | 0.333 0.489 0.179 | 0.247 0.434 0.319 |
0.208 0.542 0.250 |
0.313 0.465 0.222 | 0.373 0.429 0.198 | 0.411 0.477 0.112 | 0.420 0.449 0.131 |
| χ2 = 17.99 P<0.001 | χ2 = 4.24 P>0.1 | χ2 = 0.7 P>0.65 | χ2 = 0.17 P>0.95 | χ2 = 4.9 P>0.1 | χ2 = 3.52 P>0.15 | |||
| IL6-573 | GG GC CC | 0.733 0.247 0.021 | 0.914 0.086 0.000 |
0.990 0.010 0.000 |
0.899 0.101 0.000 | 0.923 0.077 0.000 | 0.897 0.103 0.000 | 0.897 0.103 0.000 |
| χ2= 26.62 P<0.001 | χ2 = 13.01 P<0.0025 | χ2 = 10.41 P<0.01 | χ2 = 12.41 P<0.025 | χ2 = 10.99 P<0.005 | χ2 = 10.99 P<0.005 | |||
| LPL | CC CG GG | 0.724 0.254 0.022 | 0.766 0.217 0.017 |
0.545 0.364 0.091 |
0.788 0.192 0.020 | 0.791 0.187 0.022 | 0.701 0.271 0.028 | 0.776 0.196 0.028 |
| χ2 = 4.02 P>0.1 | χ2 = 9.87 P<0.01 | χ2 = 1.67 P>0.4 | χ2 = 1.43 P>0.45 | χ2 = 2.97 P>0.2 | χ2 = 0.85 P>0.65 | |||
| PSEN1 | TT TG GG | 0.184 0.490 0.326 | 0.319 0.504 0.177 |
0.435 0.391 0.174 |
0.222 0.505 0.273 | 0.285 0.506 0.209 | 0.261 0.533 0.206 | 0.336 0.486 0.178 |
| χ2 = 54.47 P<0.001 | χ2 = 34.27 P<0.001 | χ2 = 6.05 P<0.05 | χ2 = 16.06 P<0.001 | χ2 = 13.59 P<0.0025 | χ2 = 33.73 P<0.001 | |||
A2M: alpha-2-macroglobulin; ACE: angiotensin I converting enzyme; AGT: angiotensinogen; APOC3: apolipoprotein CIII; CETP: cholesteryl ester transfer protein plasma; IL1B: Interleukin 1 beta; IL6: Interleukin 6; LPL: lipoprotein lipase; PSEN1: Presenilin 1.
Populations: 1301 healthy individuals with a Northern and Western European ancestry extracted from the HapMap-CEU study (N-W Europeans) [48]; 23 healthy individuals from France and Utah residents with European ancestry (Western Europeans) [48]; and 99, 91, 107, and 107 healthy individuals from Finland, Britain, Spain, and Italy, respectively, extracted from the 1000 Genomes database [49].