Table 4.

Genotype frequencies of APOE polymorphisms in our population and different Spanish populations of healthy individuals (Control) or individuals with Alzheimer’s disease (AD).

__	__	Genotype Frequencies								__
Gene	Genotypes	Our Study	Spanish Control	Spanish Control	Spanish Control	Spanish Control	Spanish Control	Spanish AD	Spanish AD	References
APOE	ε-2/2 ε-4/4 ε-3/3 ε-2/3 ε-2/4 ε-3/4	0.002 0.022 0.668 0.079 0.014 0.212	0.005 0.005 0.780 0.100 0.000 0.120	0.002 0.008 0.732 0.089 0.009 0.155	0.005 0.010 0.672 0.116 0.014 0.164	0.002 0.011 0.731 0.070 0.009 0.178	0.000 0.010 0.830 0.027 0.005 0.128	0.000 0.080 0.580 0.020 0.000 0.320	0.001 0.092 0.531 0.051 0.020 0.296	[51, 52, 54, 56, 58, 61] [63-67]
__	__	__	χ2 = 23.37 P<0.001	χ2 = 34.43 P<0.001	χ2 = 16.71 P<0.01	χ2 = 12.23 P<0.01	χ2 = 22.44 P<0.001	χ2 = 27.99 P<0.001	χ2 = 29.43 P<0.001	__

Spanish groups description: control (healthy) individuals from a broad distribution of Spanish regions (n=1286), and other groups from specific regions, such as Asturias (n=250), Barcelona (n=478), and Navarra (n=188). Table also includes two Spanish groups with individuals diagnosed with Alzheimer Disease from Navarra (n=98) and Asturias (n=120).