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. 2016 Apr 25;4(2):9. doi: 10.3390/medsci4020009

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Langerhans islets under 400× magnification power. (1) NC: langerhans islets are clearly defined in an organized cyto-architecture. Secretory acini, centroacinar cells and excretory ducts appear to be well defined; (2) DC: Cytotoxic effects of Streptozotocin seem to have caused a distortion in the architecture of the pancreatic tissues. The islets are greatly reduced in size and number and the islet cells appear necrotic with marked vacuolations; (3) PC: cyto-architecture appears distorted. Langerhans islets are reduced in size and number, with necrotic acinar cells and degenerate islet cells; (4) TG1: Langerhans Islets appear to be small, with minor vacuolations and cyto-architecture distortion; (5) TG2: Langerhans Islets appear to be large and defined. Minor vacuolations and cyto-architecture distortion are present. Secretory acini, centroacinar cells and excretory ducts appear to be well defined; (6) TG3: Islet cells appear to be prominent and large. Edges seem to be well defined.