Table 4.
Unadjusted and adjusted mortality rates and hazard ratios by treatment group for cases with either baseline or in-trial atrial fibrillation/flutter vs. cases with neither* in the lipid lowering trial
| Usual Care | Pravastatin | Usual Care/Pravastatin combined | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
|
|
||||||
| Mortality | ||||||
| All-cause | ||||||
| Unadjusted | 2.81(2.22,3.55) | <0.001 | 2.19(1.69,2.83) | <0.001 | 2.48(2.09,2.96) | <0.001 |
| Adjusted | 2.08(1.61,2.70) | <0.001 | 1.52(1.15,2.00) | 0.003 | 1.74(1.44,2.10) | <0.001 |
| CHD | ||||||
| Unadjusted | 2.76(1.93,3.93) | <0.001 | 3.18(2.28,4.43) | <0.001 | 2.96(2.32,3.77) | <0.001 |
| Adjusted | 1.95(1.31,2.89) | 0.001 | 2.20(1.54,3.13) | <0.001 | 2.02(1.56,2.63) | <0.001 |
| Stroke | ||||||
| Unadjusted | 4.38(2.03,9.44) | <0.001 | 2.75(1.12 – 6.76) | 0.028 | 3.52(1.96 – 6.31) | <0.001 |
| Adjusted | 3.21(1.36,7.53) | 0.008 | 1.75(0.69 – 4.41) | 0.237 | 2.38(1.28 – 4.44) | 0.006 |
| Heart Failure | ||||||
| Unadjusted | 5.26(2.28,12.13) | <0.001 | 4.07(1.64,10.13) | 0.003 | 4.64(2.51,8.60) | <0.001 |
| Adjusted | 4.41(1.83,10.61) | 0.001 | 2.40(0.85,6.78) | 0.097 | 3.22(1.66,6.24) | 0.001 |
| Other CVD | ||||||
| Unadjusted | 4.05(2.25,7.29) | <0.001 | 3.84(2.13,6.91) | <0.001 | 3.93(2.60,5.96) | <0.001 |
| Adjusted | 3.21(1.70,6.06) | <0.001 | 2.96(1.58,5.55) | 0.001 | 3.00(1.93,4.67) | <0.001 |
| Non-CVD | ||||||
| Unadjusted | 2.94(2.14,4.04) | <0.001 | 1.34(0.86,2.09) | 0.194† | 2.10(1.62,2.72) | <0.001 |
| Adjusted | 2.29(1.62,3.24) | <0.001 | 0.95(0.59,1.53) | 0.844† | 1.53(1.16,2.01) | 0.003 |
| Combined | ||||||
| Mortality/Morbidity | ||||||
| Stroke | ||||||
| Unadjusted | 1.82(1.00,3.31) | 0.052 | 1.77(0.94,3.33) | 0.076 | 1.80(1.17,2.78) | 0.008 |
| Adjusted | 1.48(0.75,2.89) | 0.256 | 1.13(0.56,2.30) | 0.736 | 1.27(0.78,2.07) | 0.338 |
| Heart Failure | ||||||
| Unadjusted | 2.96(1.82,4.82) | <0.001 | 2.51(1.49,4.21) | 0.001 | 2.74(1.92,3.90) | <0.001 |
| Adjusted | 2.69(1.58,4.56) | <0.001 | 1.46(0.81,2.64) | 0.203 | 1.97(1.33,2.91) | 0.001 |
| CHD | ||||||
| Unadjusted | 1.22(0.65,2.28) | 0.534 | 1.90(1.13,3.18) | 0.015 | 1.54(1.03,2.29) | 0.033 |
| Adjusted | 0.79(0.37,1.67) | 0.531 | 1.40(0.82,2.40) | 0.223 | 1.10(0.71,1.69) | 0.682 |
| Combined CVD | ||||||
| Unadjusted | 2.12(1.50,2.98) | <0.001 | 2.43(1.75,3.38) | <0.001 | 2.27(1.79,2.87) | <0.001 |
| Adjusted | 1.79(1.24,2.57) | 0.002 | 1.57(1.10,2.25) | 0.013 | 1.66(1.29,2.14) | <0.001 |
Abbreviations: CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio.
*
Adjusted for age, gender, race, diabetes, current smoking, history of CHD, LVH, ASCVD, aspirin use, anti-hypertensive medications, BMI, GFR and HDL
†
P-value for interaction between pravastatin vs. usual care and atrial fibrillation HR for outcome is <0.05