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. 2017 Oct 3;9:461–469. doi: 10.2147/CMAR.S113320

Figure 1.

Figure 1

Mechanism of action of TAS-102.

Note: Enzymes are italicized.

Abbreviations: TP, thymidine phosphorylase; FTY, 5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione; hENT, human equilibrative nucleoside transporter; TK, thymidine kinase; TF-TMP, trifluorothymidine monophosphate; TF-TDP, trifluorothymidine diphosphate; TF-TTP, trifluorothymidine triphosphate; TS, thymidylate synthase; dTMP, 2′-deoxythymidine-5′-monophosphate; dTTP, 2′-deoxythymidine-5′-triphosphate; dUMP, 2′-deoxyuridine-5′-monophosphate; dUTP, 2′-deoxyuridine-5′-triphosphate.