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GISTs from imatinib-resistant KitV558Δ;T669I/+ mice respond to combined PI3K and MAPK inhibition. KitV558Δ;T669I/+ mice (n = 3/group) were treated for 7 d with vehicle (Control), imatinib, or alpelisib (40 mg/kg) and binimetinib (10 mg/kg) and analyzed by immunoblotting (A), proliferation index (B), and Trichrome staining (C).
