. Author manuscript; available in PMC: 2018 Jun 15.

Published in final edited form as: Cancer Res. 2017 May 16;77(12):3151–3157. doi: 10.1158/0008-5472.CAN-17-0035

Table 1.

Transgene details and associated phenotypes

Transgene Designation(s)	Transgenic Construct(s)	Effector(s); targeted cells	Phenotype
sT	K5-sTAg-IRES-RFP	sTAg; epidermis	epidermal hyperplasia/dysplasia
tLT	K5-tLTAg	tLTAg (MCC-specific);epidermis	none apparent
sT+tLT	K5-sTAg-IRES-RFP + K5-tLTAg	sTAg + tLTAg; epidermis	epidermal hyperplasia/dysplasia
Atoh1	K5-Atoh1-IRES-GFP	Neuroendocrine cell fate determinant Atoh1; epidermis	ectopic Merkel cells
sT+Atoh1	K5-sTAg-IRES-RFP +K5-Atoh1-IRES-GFP	sTAg + Atoh1; ectopic Merkel cells	MCC-like tumors
tLT+Atoh1	K5-tLTAg + K5-Atoh1-IRES-GFP	tLTAg + Atoh1; ectopic Merkel cells	ectopic Merkel cells
sT+tLT+Atoh1	K5-sTAg-IRES-RFP + K5-tLTAg + K5-Atoh1-IRES-GFP	sTAg + tLTAg + Atoh1; ectopic Merkel cells	MCC-like tumors
sT_L142A+tLT+Atoh1	K5-sTAg_L142A-IRES-RFP + K5-tLTAg + K5-Atoh1-IRES-GFP	sTAg_L142A (PP2A binding mutant) + tLTAg + Atoh1; ectopic Merkel cells	MCC-like tumors
sT_91-95A+tLT+Atoh1	K5-sTAg_91-95A-IRES-RFP + K5-tLTAg + K5-Atoh1-IRES-GFP	sTAg_91-95A (FBXW7 binding mutant) + tLTAg + Atoh1; ectopic Merkel cells	ectopic Merkel cells