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. 2017 Oct 11;12(10):e0185786. doi: 10.1371/journal.pone.0185786

Fig 1. DUSP3 deletion accelerates experimental LLC metastasis growth.

Fig 1

LLC tumour growths were monitored by xenogen bioluminescence imaging. Tumours were established by iv injection of 106 LLC-Luc+ cells to DUSP3+/+ and DUSP3-/- mice. (A) Representative xenogen imaging results. (B) Quantification of xenogen bioluminescence imaging data shown in A at day 14 after LLC injection. (C) Representative lung macroscopic view. (D) Comparison of lung weights from DUSP3+/+ and DUSP3-/- mice. (E) Hematoxylin eosin staining of lung sections from DUSP3+/+ and DUSP3-/- mice. (F) Comparison of tumour areas from DUSP3+/+ and DUSP3-/- mice. Student t-test was used for (B) and (D) and Mann-Whitney test was used for (F). *p < 0,05, **p < 0.01. 4 mice were used in each group and for each experiment. Data shown are representative of 5 different experiments.