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. 2017 Oct 11;12(10):e0185786. doi: 10.1371/journal.pone.0185786

Fig 4. LLC metastasis growth in DUSP3-/- mice is driven by hematopoietic cells.

Fig 4

Tumours were established by injection (i.v.) of 106 LLC-Luc+ cells to DUSP3+/+ or DUSP3-/- BM-transplanted irradiated DUSP3+/+ mice. (A) Western blot analysis for DUSP3 expression from spleen lysates of transplanted mice (M = mouse). (B) Representative xenogen bioluminescence imaging results. (C) Quantitative imaging data (day 14). (D) Correlation between size of tumours (quantified as photons/second) and DUSP3 expression. (E) Comparison of lungs weights of DUSP3+/+ or DUSP3-/- BM-transplanted irradiated DUSP3+/+ mice. (F) Hematoxylin-eosin staining of lung section from DUSP3+/+ or DUSP3-/- BM-transplanted irradiated DUSP3+/+ mice. (G) Comparison of tumour areas from DUSP3+/+ or DUSP3-/- BM-transplanted irradiated DUSP3+/+ mice. Student t-test was used for (C) and (E) and Mann-Whitney test was used for (G). *p < 0,05, **p < 0.01. 4 mice were used in each group and for each experiment. Data shown are representative of 2 different experiments.