Table 4. Heritability estimation for 10 metabolic traits in 762 related Chinese and Malays.
| Trait | Sample size | OmniExpress array (435,314 SNPs) | WES target + off-target (1,054,229 SNPs) | WES target only (40,824 SNPs) |
|---|---|---|---|---|
| BMI | 762 | 0.587 (0.091)* | 0.554 (0.090) | 0.553 (0.087) |
| WHR | 762 | 0.355 (0.096) | 0.343 (0.092) | 0.319 (0.087) |
| SBP | 752 | 0.172 (0.098) | 0.164 (0.098) | 0.157 (0.090) |
| DBP | 734 | 0.262 (0.099) | 0.265 (0.097) | 0.187 (0.089) |
| TC | 761 | 0.523 (0.086) | 0.517 (0.086) | 0.438 (0.083) |
| LDL | 761 | 0.602 (0.087) | 0.593 (0.084) | 0.470 (0.086) |
| HDL | 761 | 0.658 (0.077) | 0.632 (0.077) | 0.576 (0.079) |
| TG | 628 | 0.609 (0.101) | 0.588 (0.010) | 0.534 (0.099) |
| FBG | 628 | 0.402 (0.105) | 0.378 (0.103) | 0.338 (0.101) |
| HbA1C | 683 | 0.572 (0.092) | 0.570 (0.090) | 0.549 (0.089) |
The pairwise relatedness matrix (2Φ) was estimated by PC-Relate for array genotyping data and by SEEKIN for sequencing data, based on common SNPs overlapped with the SGVP dataset. Trait heritability was estimated using a linear mixed model, adjusting for age, age2, sex, and the first two ancestry PCs.
Abbreviations of traits: BMI, body-mass index; WHR, waist-to-hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; FBG, fasting blood glucose; HbA1C, hemoglobin A1C.
* Values in the parenthesis indicate standard errors of the heritability estimates.