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. Author manuscript; available in PMC: 2018 Oct 10.
Published in final edited form as: J Control Release. 2017 Mar 27;263:18–28. doi: 10.1016/j.jconrel.2017.03.384

Fig. 2.

Fig. 2

Viability of hepatocytes (THLE-3) 24 hours after transfection with a broad range of PBAE structures and concentrations. PBAE polymers were evaluated in comparison to three commercially available non-viral transfection vectors (positive controls) at a range of dosages. Viability of cells treated with polymer 536 at a 25 polymer-to-DNA w/w ratio remained above 80%. Among the positive controls, only jetPRIME™ and PEI 25kDa at relatively low concentrations enabled comparably high viability. Results from each condition were obtained as the average metabolic activity relative to untreated controls. The proportions of Lipofectamine™ 2000-to-DNA and jetPRIME™-to-DNA in each condition are expressed as weight-to-weight and weight-to-volume ratios, respectively.