Table 2.
Variables | Frequency(n) | Percentage (%) | |
Starting dose (mg/kg/day) | |||
Less than 10mg/kg | 15 | 62.5 | |
10 – 20 mg/kg | 9 | 37.5 | |
>20mg/kg | - | - | |
Mean(SD)=10.61(3.31), Median=9.01, Min=7.35, Max=17.24 | |||
Current dose (mg/kg/day)* | |||
Less than 10mg/kg | 5 | 25.0 | |
10 – 20 mg/kg | 15 | 75.0 | |
>20mg/kg | - | - | |
Mean(SD)= 13.49(3.73), Median=15.05, Min=7.81, Max=17.86 | |||
Indications for commencement of hydroxyurea** | |||
Frequent/Severe VOC | 19 | 79.2 | |
Moderate Disease | 3 | 12.5 | |
High leucocyte/platelet Counts |
1 | 4.2 | |
Severe symptomatic anaemia |
1 | 4.2 | |
Severe/Recurrent ACS | 1 | 4.2 | |
Indications for discontinuation of hydroxyurea | |||
Conception/Fertility | 3 | 12.5 | |
Unbearable Reactions | 1 | 4.2 | |
N=24(40% of all subjects),
20 subjects on current use,
multiple responses