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. 2017 Sep 20;14(134):20170320. doi: 10.1098/rsif.2017.0320

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Individual variation of pretreatment patterns among simulated tumours in patients with different tumour neoantigen characteristics at day 30. A tumour slice from a patient with (a) tumour neoantigens of low mutational burden and high antigen strength; (b) high mutational burden and high antigen strength; (c) low mutational burden and low antigen strength; (d) high mutational burden and low antigen strength.