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. 2017 Sep 20;14(134):20170320. doi: 10.1098/rsif.2017.0320

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 6. — Regionalization and scoring simulated tumour. (a) Tumour boundary is detected from spatial distribution of cells from simulation, and a Euclidian distance map is calculated for the distance to surface from every point inside the tumour. Sub-regions can be selected by thresholding the distance of interest (100 µm is used in this example). Regionalized PDL1 score as a potential biomarker for anti-PD1 treatment. (b) Simulated treatment outcome. Colour indicates reduction in total cancer cell count at day 50 with anti-PDL1 treatment versus day 30 (pretreatment). (c) Score obtained by regionalizing tumour, calculated as the fraction of PDL1⁺ cancer cells within the rim of designated thickness. 50 μm distance cut-off is used in this figure. (d) ROC curves of different cutoff distances.