MRI evaluation of the tumour volume. Left panels: Representative T2w MRI images for the 5 different groups of mice before treatment, D0 (A), and at late times, D6 (B), D13 (C), D27 (D), after the administration of the treatments. Right panels: Quantitative analyses of tumour volume at D0 and the percentage of increase or decrease of tumour volume in comparison to pretreatment at D6, D13 and D27. Mean ± SD, n = 3 for the Control group, n = 5 for the EBRT alone and EBRTt1 + MRT groups and n = 6 for MRT alone and MRT + EBRTt2 groups. **p < 0.01 and ***p < 0.001 versus Control group, ###p < 0.001 versus MRT group, &&&p < 0.001 versus MRT + EBRTt2 and $$$p < 0.001 versus EBRT alone group for time effect.