Table 2.
Cardiac stem cells subtypes based on antigenic characteristics.
| Subtype | cKit | CD34 | Sca-1 | Abcg2 | Wt1 | CD105 | GATA4 | MEF2C | NKX2–5 | CD166 | CD45 | PDGFRα | CD90 | FLK1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| c-Kit CSCs | + | − | + | + | − | + | + | + | ± | + | − | + | ± | ± |
| Sca-1 CSCs | low | − | + | ± | + | + | low | − | + | − | ||||
| Side population | + | + | + | + | ± | − | − | + | + | |||||
| Cardiosphere-derived cells | low | + | + | + | + | + | ||||||||
| Cardiac resident colony-forming unit-fibroblast | low | + | + | + | − | + | + | − | ||||||
| Isl-1pos cardiac progenitor cells | − | − | + | + | ||||||||||
| Epicardial stem cells | − | + | + |
C-kit + CSCs (Beltrami et al., 2003, Ellison et al., 2013) Sca1pos CSCs (Oh et al., 2003); side population (SP) cells) (Martin et al., 2004); Cardiosphere-derived cells (Chimenti et al., 2012); cardiac resident colony-forming unit-fibroblast (cCFU-Fs) (Chong et al., 2011); and the Isl-1pos cardiac progenitor cells (Laugwitz, Moretti, Caron, Nakano, & Chien, 2008); Epicardial stem cells (Smart et al., 2011).