Table 5.
Associations of thyroid cancer with underlying medical indication for transplant among kidney and liver recipients
| Total thyroid cancer | Papillary carcinoma | Local | Regional/distant | |||||
|---|---|---|---|---|---|---|---|---|
| Indication for transplant | Cases | IRR (95%CI)a | Cases | IRR (95%CI)a | Cases | IRR (95%CI)a | Cases | IRR (95%CI)a |
| Kidney recipients | ||||||||
| Glomerular diseases | 73 | 0.97 (0.75–1.27) | 67 | 0.97 (0.74–1.28) | 56 | 1.13 (0.83–1.55) | 16 | 0.74 (0.44–1.25) |
| Diabetes mellitus | 36 | 0.78 (0.56–1.09) | 27 | 0.65 (0.44–0.94) | 23 | 0.76 (0.50–1.16) | 11 | 0.80 (0.44–1.47) |
| Hypertensive nephrosclerosis | 45 | 1.41 (1.03–1.94) | 43 | 1.50 (1.08–2.07) | 30 | 1.38 (0.93–2.05) | 12 | 1.39 (0.77–2.54) |
| Polycystic kidney disease | 21 | 0.78 (0.51–1.17) | 20 | 0.81 (0.53–1.24) | 13 | 0.74 (0.44–1.25) | 6 | 0.77 (0.36–1.67) |
| Tubular and interstitial diseases | 16 | 1.00 (0.63–1.58) | 16 | 1.08 (0.68–1.72) | 12 | 1.13 (0.66–1.94) | 4 | 0.89 (0.36–2.19) |
| Vascular diseases | 11 | 1.37 (0.80–2.36) | 9 | 1.25 (0.69–2.27) | 9 | 1.69 (0.91–3.11) | 2 | 0.90 (0.26–3.13) |
| Congenital/familial/metabolic disorders | 6 | 0.83 (0.40–1.73) | 6 | 0.90 (0.43–1.87) | 3 | 0.62 (0.22–1.73) | 3 | 1.47 (0.50–4.29) |
| Other/unknown conditions | 29 | 1.06 (0.74–1.51) | 27 | 1.08 (0.74–1.56) | 17 | 0.95 (0.60–1.52) | 11 | 1.35 (0.74–2.46) |
| Liver recipients | ||||||||
| Cholestatic liver disease/cirrhosis | 14 | 1.69 (1.09–2.63) | 12 | 1.58 (0.99–2.54) | 9 | 1.66 (0.95–2.88) | 4 | 1.73 (0.77–3.89) |
| Noncholestatic cirrhosis | 26 | 0.81 (0.56–1.18) | 23 | 0.81 (0.55–1.21) | 16 | 0.79 (0.50–1.27) | 10 | 1.04 (0.54–2.03) |
| Other/unknown conditions | 13 | 0.73 (0.46–1.15) | 12 | 0.78 (0.48–1.25) | 8 | 0.76 (0.43–1.35) | 4 | 0.55 (0.24–1.29) |
Abbreviations: CI, confidence interval; IRR, incidence rate ratio
a
IRRs were adjusted for attained age, sex, race/ethnicity, transplanted organ, time since transplant, and year of transplantation and were modeled using effect parameterization, which compares each category to the average of all of the categories.