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. 2017 Sep 12;9(9):1957–1970. doi: 10.18632/aging.101282

Figure 7. A model of the Brca1 gene downregulation by pyridostatin.

Figure 7

(A) Transcription of the Brca1 gene in primary neurons under basal conditions. (B) Pyridostatin binds to and stabilizes the G-quadruplex structures present in the Brca1 gene promoter sequence. The pyridostatin/DNA complex stalls DNA polymerase during transcription and downregulates Brca1 gene expression. (1) Brca1 downregulation may then hinder DNA damage repair and DNA DSBs accumulate as a result. (2) In addition, DNA damage may occur due the action of endo-nucleases through a mechanism of transcription–coupled–repair poisoning [25].