Table 3. Association of the haplotypes derived from six independent SNPs in RET identified in current study.
| rs2506030 | rs2435357 | rs2505532 | rs1800860 | rs2742234 | rs2742236 | F_A | F_U | P | OR | P_OMNIBUS |
|---|---|---|---|---|---|---|---|---|---|---|
| Risk haplotype* | 2.12E-75 | |||||||||
| G | T | C | G | C | G | 0.56 | 0.35 | 5.18E-54 | 2.37(2.05~2.76) | |
| A | T | C | G | C | G | 0.1 | 0.08 | 7.77E-03 | 1.29(1.00~1.67) | |
| Protective haplotype* | ||||||||||
| G | C | T | G | T | A | 0.1 | 0.19 | 9.35E-22 | 0.46(0.37~0.57) | |
| A | C | T | G | T | G | 0.04 | 0.07 | 7.39E-10 | 0.46(0.33~0.65) | |
| G | C | T | A | T | G | 0.05 | 0.07 | 5.40E-05 | 0.62(0.45~0.85) | |
| G | C | C | A | T | A | 0.02 | 0.05 | 5.65E-06 | 0.50(0.33~0.75) | |
* Haplotypes with minor haplotype frequency in controls larger than 0.05 were shown.
F_A/F_U indicates risk haplotype frequency of the SNP in cases or controls. The P value indicates the significance based on haplotypic association tests.
P_OMNIBUS indicates the omnibus association significance across all the risk haplotypes and protective haplotypes.