Table 5. The association results of six independent SNPs in RET to different subclinical features classified by aganglionosis length including short-length(S-HSCR), long-length (L-HSCR) and TCA.
| SNP | P_Quantitative | S-HSCR | L-HSCR | TCA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1033 cases | 294 cases | 82 cases | |||||||||
| A1/A2 | F_A | P | OR | F_A | P | OR | F_A | P | OR | ||
| rs2506030 | G/A | 6.40E-03 | 0.81 | 1.70E-08 | 1.52 | 0.8 | 1.40E-02 | 1.33 | 0.71 | 0.42 | 0.86 |
| rs2435357 | T/C | 4.20E-05 | 0.74 | 5.10E-64 | 3.16 | 0.68 | 7.00E-19 | 2.55 | 0.59 | 4.10E-04 | 1.87 |
| rs2505532 | C/T | 5.30E-03 | 0.77 | 8.10E-37 | 2.38 | 0.72 | 1.20E-10 | 2.01 | 0.68 | 5.70E-03 | 1.67 |
| rs1800860 | G/A | 6.90E-02 | 0.85 | 9.70E-09 | 1.59 | 0.83 | 5.10E-03 | 1.43 | 0.8 | 0.7 | 1.09 |
| rs2742234 | C/T | 2.40E-03 | 0.71 | 2.60E-45 | 2.58 | 0.66 | 5.10E-12 | 2.03 | 0.62 | 1.40E-03 | 1.76 |
| rs2742236 | G/A | 1.40E-03 | 0.83 | 6.70E-27 | 2.27 | 0.77 | 8.50E-05 | 1.56 | 0.77 | 1.80E-02 | 1.62 |
P_Quantitative: The patient-only linear regression test among three subclinical groups including S-HSCR, L-HSCR and TCA; F_A indicates risk allele frequency of the SNP in each subclinical group.