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. Author manuscript; available in PMC: 2018 Nov 4.
Published in final edited form as: Biochem Biophys Res Commun. 2017 Sep 1;493(1):598–603. doi: 10.1016/j.bbrc.2017.08.146

Figure 4. Attenuated AHR and fibrosis in an acute model of allergic asthma in KLF4 knockout mice, accompanied by significantly decreased numbers of fibrocytes.

Figure 4

A. Measurement of specific airway resistance (sRaw) by non-invasive whole-body plethysmography in the WT and KLF4−/− mice upon OVA challenge as described in the Materials and Methods. B. IL-13 expression levels in the lungs of the wild type (WT) and KLF4−/− mice upon control or OVA challenge were assessed by qRT-PCR. n=3, *p<0.05. C. Trichrome staining to examine lung fibrosis before and after OVA challenge in WT and KLF4−/− mice. Arrows point to possible fibrotic areas. D. After gating CD11b+Ly6G+ MDSCs, populations of CCR2+MDSCs in the lungs of WT and KLF4−/− mice before and after OVA challenge were measured by flow cytometry. E. Simiar to D, CD45+COL1A1+ fibrocytes in the lungs were measured by flow cytometry.