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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Lab Chip. 2017 Oct 11;17(20):3474–3488. doi: 10.1039/c7lc00694b

Figure 7.

Figure 7

(A) Schematic of the experimental design for collective cell migration from initially straight or convex geometries. Alginate structures were printed, cells seeded around the printed structures, and allowed to grow to 90% confluency. Alginate structures were then degraded using 10mM EDTA, and cells allowed to migrate into the empty space over time. Red boxes indicate an example of the field of view imaged. Black arrows indicate direction of cell migration. (B–E) Representative fluorescence microscopy images of MCF-10A cell front migration at 12 hr timepoints. (B) DMSO control from initially straight geometries, (C) OHT treatment from initially straight geometries. (D) DMSO control from initially convex geometries, (E) OHT treatment from initially convex geometries.