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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: Dev Growth Differ. 2017 May 17;59(4):194–210. doi: 10.1111/dgd.12351

Table 1.

Description of protein names, standard abbreviations, conventional zebrafish names (https://zfin.org) and function of endocannabinoid related genes investigated in this study.

Protein Name Standard Abbreviation ZFIN Gene Name Function
cannabinoid receptor 1 CB1 cnr1 G-protein coupled receptor located primarily in the CNS; activated by endogenous and exogenous cannabinoids
cannabinoid receptor 2 CB2 cnr2 G-protein coupled receptor located primarily in peripheral organs of the immune system and in the brain; activated by endogenous and exogenous cannabinoids
G protein-coupled receptor 55a GPR55A gpr55a G- protein coupled receptor widely expressed in the brain; recently found to be activated by endogenous and exogenous cannabinoids; its activation leads to stimulation of rhoA, cdc4 and rac1
cannabinoid receptor interacting protein 1a CRIP1A cnrip1a CB1 receptor interacting protein that interacts with the distance C-terminus of CB1 altering/modulating CB1 interactions with G-protein
monoglyceride lipase MGLL (MAGL) mgll member of the serine hydrolases superfamily; it catalyzes the hydrolysis of 2-AG to AA and Glycerol
αβ-hydrolase domain containing 6b ABHD6B abhd6b member of the serine hydrolases superfamily; itcatalizes the hydrolysis of 2-AG to AA and Glycerol
αβ-hydrolase domain containing 12 ABHD12 abhd12 member of the serine hydrolases superfamily; it catalyzes the hydrolysis of 2-AG to AA and Glycerol in the CNS
diacylglycerol lipase, alpha DAGLα dagla diacylglycerol lipase; it catalyzes the hydrolysis of diacylglycerol (DAG) to the most abundantendocannabinoid 2-AG
diacylglycerol lipase, beta DAGLβ daglb diacylglycerol lipase; it catalyzes the hydrolysis of diacylglycerol (DAG) to the most abundant endocannabinoid 2-AG
fatty acid amide hydrolase FAAH faah fatty acid amide hydrolase with a single N-terminal transmembrane domain; principal catabolic enzyme for a class of lipids known as fatty acid amides (FAAs) of which AEA belongs to
fatty acid amide hydrolase 2a FAAH2A faah2a fatty acid amide hydrolase; it degrades bioactive fatty acid amides, including AEA (AEA = arachidonic acid + ethanolamine)
N-acyl phosphatidylethanolamine phospholipase D NAPE-PLD napepld member of the metallo-beta-lactamase family with phosphodiesterase activity; it releases NAE from NAPE to for AEA
αβ-hydrolase domain containing 4 ABHD4 abhd4 hydrolase that acts on either NAPE or lyso-NAPE to generate the glycerophospho-arachidonoyl ethanolamide which is subsequently cleavaged to give AEA
glycerophosphodiester phosphodiesterase 1 GDE1 (MIR16) gde1 phosphodiesterase with glycerophospho-NAE phosphodiesterase activity; ithydrolyses the phosphodiesterase bond of GP-NArE to release free AEA
prostaglandin-endoperoxide synthase 2 a PTGS2A (COX-2; COX-2A) ptgs2a cycloxigenase involved in AEA (and 2-AG?) metabolism
N-acylsphingosine amidohydrolase (acid ceramidase) 1a NAAA1A (ASAH1A) asah1a member of the choloylglycine hydrolase family with similar structure to faah. Unlike faah, naaa1a operates in acidic environments (pH 4.5)
protein tyrosine phosphatase, non-receptor type 22 PTPN22 ptpn22 protein tyrosine phosphase highly expressed in the immune system; it dephosphorylates pAEA to yield AEA
peroxisome proliferator-activated receptor alpha b PPARαβ pparab nuclear receptor transcription factor protein suggested as a binding target of endocannabinoids
peroxisome proliferator-activated receptor gamma PPARγ (ARF6) pparg nuclear receptor transcription factors protein suggested as a binding target of endocannabinoids
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