TABLE 2.
Transgenic mouse models with spontaneous or deficient ocular angiogenesis
| Gene | Mouse model | Disease/pathologic feature | Reference |
|---|---|---|---|
| Spontaneous intraretinal/ subretinal angiogenesis | |||
| Vldlr | Vldlr−/− | RAP, AMD | 111, 102, 101, 114, 116, 119 |
| Vegf | rho/VEGF transgenic | RAP, AMD | 104 |
| Unknown | JR5558 (NRV2) | RAP, AMD | 129–131 |
| Deficient intraretinal angiogenesis | |||
| Lrp5 | Lrp5−/− | FEVR | 146, 148, 149, 153 |
| Norrin | Ndpy/− | Norrie disease | 143, 147, 153 |
| Fzd4 | Fzd4−/− | FEVR | 143, 153 |
| Tspan12 | Tspan12−/− | FEVR | 151 |
| Girdin (Ccdc88a) | Girdin−/− | Incomplete retinal vessel development | 163 |
| Girdin-KISA/SA | 164 | ||
| Spontaneous corneal angiogenesis | |||
| Destrin | Corn1 | Spontaneous corneal neovascularization | 194 |
| Cd36 | Cd36−/− | 195 | |
| Pax6 | Pax6 Tg | 196 | |
| Flt1 | NLS-Cre;flt-1loxP/loxP | 171 | |
| Kdr | LeCre;vegfr2loxP/loxP | 197 |
NRV2, neoretinal vascularization 2.