Figure 5.

RPE promotes the suppressive phenotype of γδ T cells in an AhR-dependent manner. A) Schematic illustration of cocultured splenic γδ T cells with RPE explants. B) Cytokine gene expressions of γδ T cells were measured from either wild-type or AhR^−/− mice after coculturing with RPE explants for 16 h. C) RPE flat mounts of NaIO₃-injected mice with intravitreal delivery of either IL-4 plus IL-10 cocktail or vehicle control. RPE lesions are outlined in yellow. Subretinal microglia infiltration were measured by ionized calcium-binding adapter molecule 1 staining (n = 6). Scale bars: 200 μm; insert, 20 μm.