Figure 5.

Conditional deletion of Nrf1 leads to male infertility. A) Gross morphology of testes from mice at 7 wk after birth. B) Histologic images of testicle sections or epididymis from wild-type mice or mice with Nrf1 deletion were obtained at different time points after birth. C, D) TUNEL assays (C) or PCNA staining (D) were performed on testes from wild-type control and mice with conditional Nrf1 deletion at various postnatal time points. Scale bars, 50 μm, testicle sections; 100 μm, epididymis sections.