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Schematic view of neutrophil–endothelial adhesion and transmigration. A) Under resting conditions, ICAM-1, SHP-2, and VE-cadherin form a complex in endothelial cells. ICAM-1 distributes uniformly on cells and VE-cadherin also localizes in sequence. B) In contrast to resting conditions, neutrophil–endothelial adhesion leads to ICAM-1–SHP-2–VE-cadherin complex disassembly, an increase in VE-cadherin–actin interaction, ICAM-1 cluster formation, and VE-cadherin behaving like a curtain.
