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The mechanism underlying non-motor symptoms may be reflected in the progression of α-synuclein deposition (Braak stage). LC locus coeruleus, MCRF magnocellular reticular nucleus, NBM nucleus basalis of Meynert, OB olfactory bulb, PPN pedunculopontine nucleus, RN raphe nucleus, SLD sub-laterodorsal nucleus, SN substantia nigra, VN vagus nerve.
