Fig. 5.

Co-localization of α-syn and phosphorylated α-Syn (P-α-syn) in transgenic mice at indicated ages. A–B Photomicrographs acquired under a confocal microscope show increased phosphorylation of α-syn with age (A, 3 months; B 24 months) in the mucous layer and in Auerbach’s plexus of the distal segment of the small intestine. Subsets of pan-α-syn-positive are overlapped with phospho-α-syn-positive profiles (A–C). Scale bars 2.5 μm (A), 10 μm (B), and 50 μm (C).