Fig. 3.

Lifelong treatment with rapamycin preserves alveolar bone levels in UM-HET3 mice. a Representative buccal aspect scans from 35 to 37-month female UM-HET3 mice treated either drug-free control chow (n = 5) or 42 ppm encapsulated rapamycin (n = 6) beginning at 9 months of age. Visual inspection indicates preservation of alveolar bone levels in rapamycin-treated mice compared to vehicle controls. b Representative palatal aspect scans. c Boxplot showing total distance measured from CEJ-ABC for the buccal aspect only. Rapamycin-treated animals had significantly greater alveolar bone levels compared to controls (p < 0.005)