Fig. 4.

The different architectures of multi-domain NRs on DNA. a–d Crystal structures of RARβ–RXRα heterodimer (a), PPARγ–RXRα heterodimer (b), and HNF-4α homodimer (c) on DR1 DNA, and that of LXRβ-RXRα heterodimer on DR4 DNA (d). The AGGTCA sites are colored in blue for each structure. e–h Relative positions of LBDs and DBDs of RARβ (e), PPARγ (f), LXRβ (g), and HNF-4α (h). All the LBDs are in the same orientation, with their α9 and α10 helices labeled, and their “patch” regions highlighted with clear ovals. For HNF-4α homodimer, one DBD is shown near to the LBDs from the same monomer (in wheat color) or from the other one (in cyan)