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. 2017 Oct 11;7:12981. doi: 10.1038/s41598-017-12819-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MDCKI cells expressing K706R, K828R and K909R mutants have significantly higher ²²Na fluxes relative to WT-NCC expressing cells. Quantitative assessment of ²²Na uptake in various MDCKI cells in the presence (+) or absence (−) of metolazone (Met) in the uptake medium. Data were analyzed using a two-way ANOVA followed by Tukey-Kramer multiple comparison test. Data are means ± S.E.M. (n = 12–24). *Represents significant difference compared to without metolazone condition. ^#Represents significant differences compared to WT-NCC without metolazone.