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. 2017 Oct 11;7:12961. doi: 10.1038/s41598-017-13210-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The frequency of important n-grams used by the best-performing classifier in amyloid and non-amyloid sequences. Amino acids possible on a given position of the n-grams are specified inside the brackets. X denotes any amino acid. The frequency was computed using the total number of occurrences divided by the number of possible n-grams of their length. Open and closed circles denote experimentally validated n-grams occurring in motifs found in amyloidogenic and non-amyloidogenic sequences, respectively³⁰.