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. 2017 Oct 11;7:12996. doi: 10.1038/s41598-017-13522-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bioluminescence and graft survival rate after transplantation of fetus-NSPCs and iPSC-NSPCs into syngeneic and allogeneic mice. (A,B) Bioluminescence images of representative mice at 0, 14, 28, 56, and 84 days after transplantation, and quantitative analyses of CPM derived from grafted fetus-NSPCs and two lines of iPSC-NSPCs (2A3F and 2A4F) in subcutaneous lesions and spinal cords (black line = syngeneic transplantation; red line = allogeneic transplantation). (C,D,E) Graft survival rates after transplantation into subcutaneous lesions (C) and spinal cords (D and E). The black line shows the fetus-NSPCs transplantation group, the blue line shows the 2A3F iPSC-NSPCs transplantation group, and the red line shows the 2A4F iPSC-NSPCs transplantation group. Values represent the mean ± SEM. *P < 0.05, one-way ANOVA followed by the Tukey–Kramer test. The graft survival rates were assessed using Kaplan–Meier survival curves. *P < 0.05, Gehan-Breslow-Wilcoxon test. ns, not significant. In (A–E), N indicates the number of mice.