Figure 6.
Bioimaging and graft survival rate after transplantation of fetus-NSPCs and iPSC-NSPCs into intact and injured spinal cords (with or without FK506) in MHC-mismatched BALB/cA mice. Quantitative analyses of the CPM derived from grafted (A) fetus-NSPCs and (B) 2A4F iPSC-NSPCs. Graft survival rates of mice transplanted with (C) fetus-NSPCs and (D) 2A4F iPSC-NSPCs. Each of the same populations of fetus-NSPCs and 2A4F iPSC-NSPCs were transplanted into intact spinal cords (intact spinal cord group, black), injured spinal cords (injured spinal cord group, red), and injured spinal cords in the presence of FK506 (injured spinal cord + FK506 group, blue) in BALB/cA mice. Follow-up examinations were performed using bioimaging. Values represent the mean ± SEM. *P < 0.05, one-way ANOVA followed by the Tukey–Kramer test. The graft survival rates were assessed using Kaplan–Meier survival curves. *P < 0.05, Gehan-Breslow-Wilcoxon test. ns, not significant. In (A–D), N indicates the number of mice.