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. 2017 Oct 11;7:13004. doi: 10.1038/s41598-017-12532-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Molar pattern in the MRCS1 KO homozygote and the compound heterozygote of MRCS1 and Shh KO alleles. Occlusal views of maxilla in the wild type mouse (a), the MRCS1 KO homozygote (b, ΔMRCS1/ΔMRCS1) and the compound heterozygote (c, ΔMRCS1/ShhKO) at one month old. Molar pattern in the mandible of the wild type (d,g,j), the MRCS1 KO homozygote (e,h,k) and the compound heterozygote (f,i,l). Three-dimensional reconstructions of X-ray micro CT images of molars are shown in g–l. Arrowheads mark supernumerary teeth. The alleles of the compound heterozygote of the ΔMRCS1 and the Shh coding sequence KO alleles are schematically illustrated in Supplementary Fig. 1d. M1, first molar; M2, second molar; M3, third molar.