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. 2017 Jul 25;95(9):775–788. doi: 10.1038/icb.2017.50

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Decreased peritoneal B-1 B cells in LRBA-deficient mice. Flow cytometric analysis of peritoneal cavity lymphocytes from sex-matched WT (red) and Lrba^−/− (blue) mice at 6 (n=6) or 26 (n=4) weeks of age, showing individual results and means for each group. (a and b) Percentage of lymphocytes that are T cells (B220⁻ IgM⁻ CD23⁻ CD5⁺), B-2 cells (CD19⁻B220^hi), B-1 cells (CD19⁺ B220^lo IgM⁺ CD23⁻), B-1a cells (CD19⁺ B220^lo IgM⁺ CD23⁻ CD5⁺) and B-1b cells (CD19⁺ B220^lo IgM⁺ CD23⁻ CD5⁻). (c and d) Representative flow cytometric plots showing gating IgM, CD23, B220 and CD19 staining for B-1 and B-2 cells and representative CD5 histograms of B-1 cells showing gates on CD5+ B-1a and CD5- B-1b cells from mice at 6 (c) and 26 (d) weeks of age. Statistical analysis was carried out using t-test: *P<0.05; **P<0.01. Data are representative of one experiment.