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. 2017 Sep 7;8(9):e3046. doi: 10.1038/cddis.2017.382

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Expression profiles of lncRNAs in RPE differentiation. (a) Hierarchical clustering of all 217 lncRNAs with a consistent expressional change along with the differentiation. Thirteen lncRNAs with consistent fold change of over 2 are highlighted. Blue: downregulated lncRNAs; yellow: upregulated lncRNAs. (b) Chromosomal locations of the 217 differentially expressed lncRNAs are shown as a Circos plot. (c–o) The 13 lncRNAs with consistent fold change of over 2 are selected for validation of the microarray results in hiPSC-RPE at 0, 30, 60, and 90 d.p.d., including upregulated RP11-367G18.1 (c), CTD-2319I12.1 (d), RP3-395M20.8 (e), RP11-1020M18.10 (f), H19 (g), RP11-195B3.1 (h), RP11-554I8.2 (i), and ZNF503-AS1 (j), and downregulated ESRG (k), LINC00617 (l), RP11-469A15.2 (m), LINC01162 (n), and LINC00173 (o)