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. 2017 Sep 7;8(9):e3046. doi: 10.1038/cddis.2017.382

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ZNF503-AS1 promotes RPE differentiation. (a and b) Relative miRNA expression of ZNF503-AS1 in hiPSC-RPE at 30 d.p.d. transfected with Ac-ZNF503-AS1 plasmid compared to empty vector (a), and in cells transfected with ZNF503-AS1 siRNA compared to scramble siRNA (b). (c) Relative mRNA expressions of RPE dedifferentiation-related markers, including MITF, SOX2, POU5F1, and NANOG, in hiPSC-RPE at 30 d.p.d. transfected with ZNF503-AS1 siRNA compared to scramble siRNA. (d–g) Relative mRNA expressions of RPE65, RLBP1, LRAT, MERTK, BEST1, KRT18, TJP1, and CTNNB1 in hiPSC-RPE at 30 d.p.d. (d) and ARPE19 cells (e) transfected with Ac-ZNF503-AS1 compared with empty vector, and in hiPSC-RPE at 30 d.p.d. (f) and ARPE19 cells (g) transfected with ZNF503-AS1 siRNA compared to scramble siRNA. (h–j) Relative protein expressions of Mertk, cytokeratin-18, ZO-1, and β-catenin in ARPE19 cells transfected with Ac-ZNF503-AS1 compared with empty vector (h and i), and in cells transfected with ZNF503-AS1 siRNA compared to scramble siRNA (h and j)