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. 2017 Sep 7;8(9):e3039. doi: 10.1038/cddis.2017.393

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Tumorigencity of LGR5^LGR5+ and AcGFP^LGR5^– cells from two cervical cancer cell lines in NOD/SCID mice. (a) The volume of xenograft tumors formed by different numbers of LGR5^LGR5+ and AcGFP^LGR5− cervical cancer cells was monitored over time. (b) Kaplan–Meier plots showing the tumor-free survival after injection. (c, d) Immunohistochemical staining and western blot for LGR5 in tumor tissues, scale bar, 10 μm. *P<0.05; **P<0.01; ***P<0.001. Data represent mean±S.D. of tumor volumes at different time points of eight mice in each group