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. 2017 Sep 7;8(9):e3039. doi: 10.1038/cddis.2017.393

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Elevated LGR5 expression protects cervical cancer cells to resist cisplatin. (a) Cell viability of the LGR5-overexpressing and LGR5-knockdown cervical cancer cells was measured using an MTT assay after treatment with different concentrations of cisplatin for 24 h. (b) Cell viability of the LGR5-overexpressing and LGR5-knockdown cervical cancer cells was measured using an MTT assay after treatment with a constant dose of cisplatin for 0, 24, 48 or 72 h. Data represent mean±S.D. of triplicate experiments. (c) The percentage of LGR5⁺ cells in the cervical cancer cell lines was analyzed by flow cytometry after exposure to 3 μg/ml cisplatin for 2 days and following culture in ordinary culture medium for 2 weeks. *P<0.05; **P<0.01; ***P<0.001