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. 2017 Sep 7;8(9):e3039. doi: 10.1038/cddis.2017.393

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Elevated LGR5 promoting cervical cancer cell stemness associated with the Wnt/β-catenin pathway. (a, b) Western blot analysis of the protein levels of the stem cell-associated transcription factors OCT4, NANOG, KLF4, ALDH and BMI1 in the LGR5-overexpressing and LGR5-knockdown cervical cancer cells. β-actin was used as a loading control. (c–f) The expression of β-catenin in LGR5-overexpressing cervical cancer cell lines and control cells cultured with or without DDK-1 or CHIR-99021. (g, h) The tumorsphere-forming efficiency in modified cervical cancer cells was evaluated after change of Wnt/β-catenin pathway. Values are shown as the mean±S.D. of three experiments in duplicate. *P<0.05, **P<0.01; ***P<0.001 versus control using One-Way ANOVA