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. 2017 Sep 7;8(9):e3033. doi: 10.1038/cddis.2017.424

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Reg3g activated epidermal growth factor receptor/janus kinase 2/signal transducer and activator of transcription 3 (EGFR/JAK2/STAT3) signal pathway in tumors. (a) Expressions of phosphorylated (p)STAT3, STAT3, pJAK2, JAK2, Foxp3, caspase-3, Ki67, and EGFR were analyzed by western blot in tumors of orthotopic (the left) or ectopic (the right) pancreatic tumor mice. (b) The column chart was a quantitative analysis of the western blot corresponding to (a). (c) Reg3g promoted pancreatic tumor progression and inhibited antitumor immunity by triggering the activation of STAT3 signaling. Data were represented as means±S.D. from at least three independent experiments. *P<0.05, compared with the control group; ^#P<0.05, ^##P<0.01 compared with the model group