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. 2017 Sep 7;8(9):e3035. doi: 10.1038/cddis.2017.433

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Altered peptide peaks identified by MALDI-IMS. (a) Representative hematoxylin and eosin (H&E) staining images for OSCC areas and the adjacent noncancerous areas. The areas used for MALDI-IMS analyses were labeled by black dotted lines. The OSCC and adjacent noncancerous areas selected for identifying altered peaks were labeled by dark red or light green dotted line, respectively. Scale bar: original images, 250 μm; enlarged images, 50 μm. (b) Representative MALDI-MS images of 18 peaks with most significant alterations. Sample cases 1 and 2 are the same samples as shown in (a). The corresponding m/z value of each peak was shown under the image. (c) Intensities of 67 altered peaks. a.u., Arbitrary unit