Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 7;8(9):e3035. doi: 10.1038/cddis.2017.433

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

LRP6 upregulation is correlated with OSCC development. (a) Representative images of LRP6 immunostaining of OSCC tissues and normal oral mucous tissues. Scale bar: left panels, 500 μm; right panels, 100 μm. (b) LRP6 immunostaining scores in OSCC tissues and normal oral mucous tissues were analyzed. (c) LRP6 immunostaining scores in well, moderately or poorly differentiated tumors were analyzed. WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated. (d) LRP6 immunostaining scores in OSCC patients with or without smoking were analyzed. (e) The representative p16-negative or -positive staining results and the corresponding LRP6 staining results. (f) Left: the relative LRP6 expression level in HPV p16-positive or -negative OSCC tissues was compared. Right: the relative LRP6 expression level in OSCC tissues with high or low p16 expression was compared. (g) Pearson's test was used to analyze the correlations between the LRP6 and HPV P16 expression level. (h) LRP6 immunostaining scores in tumors with or without lymph node metastasis were analyzed. LN Met, lymph node metastasis. (i) Overall survival time of OSCC patients with high or low LRP6 expression was analyzed by Kaplan–Meier analysis. (j) LRP6 immunostaining scores in OSCC patients with or without drinking were analyzed. (k) Survival time of tongue cancer patients with high or low LRP6 expression was analyzed. (l) Survival time of metastasis-free OSCC patients with high or low LRP6 expression was analyzed