Figure 6.

Expression of LRP6 is positively associated with proto-oncogenic protein FGF8. (a) Representative images of LRP6 and FGF8 immunostaining in OSCC tissues and normal oral mucous tissues using sister slides. Scale bar: left panels, 500 μm; right panels, 100 μm. (b) Immunofluorescent staining of FGF8 (green) and LRP6 (red) in OSCC tissues. The cells with both high FGF8 and LRP6 expression are circled, and the arrowheads indicate the cells with both low FGF8 and LRP6 expression. (c) Overall survival time of OSCC patients with high LRP6 expression alone, low LRP6 expression alone, concurrent high LRP6/FGF8 expression or concurrent low LRP/FGF8 expression was analyzed. (d) Survival time of tongue cancer patients with high LRP6 expression alone, low LRP6 expression alone, concurrent high LRP6/FGF8 expression and concurrent low LRP/FGF8 expression was analyzed. (e) Overall survival time of OSCC patients with high FGF8 expression alone, low FGF8 expression alone, concurrent high LRP6/FGF8 expression or concurrent low LRP/FGF8 expression was analyzed. (f) Survival time of tongue cancer patients with high FGF8 expression alone, low FGF8 expression alone, concurrent high LRP6/FGF8 expression and concurrent low LRP/FGF8 expression was analyzed