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. 2017 Sep 7;8(9):e3035. doi: 10.1038/cddis.2017.433

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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FGF8 is required for LRP6-induced proliferation in OSCC cell lines. (a) LRP6 expression plasmid was transfected into HSC-3 and HSC-4 cell lines. The expression level of LRP6 and FGF8 was detected via western blot (WB). (b) Two small interfering RNAs (siRNAs) targeting FGF8 were tested and the knockdown efficiencies were validated via WB. (c and d) HSC-3 and HSC-4 cell lines were transfected with LRP6 expression vector with or without FGF8 siRNA, and cell proliferation were detected by Cell Counting Kit-8 (CCK8) (c) and colony formation assays (d)