Table 3.

Summary of neuroanatomical associations of auditory task performance in the patient cohort.

Regional association	Area	Side	Cluster (voxels)	Peak (mm)			Z score	P value
				x	y	z
SEMANTIC CONGRUITY
Parieto-temporal	Precuneus	L	609	−3	−70	33	4.86	0.032
	SMG	L	757	−58	−20	33	4.83	0.036
	PCC	L	59	−10	−58	22	4.51	0.005
		L	497	−6	−34	34	4.33	0.009
		R	276	2	−34	34	3.91	0.038
	Retrosplenial	L	27	−12	−42	4	4.15	0.017
	Post STG/STS	L	327	−57	−48	22	4.48	0.005
Ant temporal	Ant STS	L	100	−62	−6	−15	4.11	0.018
	Temporal pole	R	908	24	−2	−45	4.14	0.030
Insula	Ant insula	L	428	−34	2	−2	3.84	0.025
		R	546	38	18	−14	3.90	0.014
	Post Insula	R	65	39	−15	8	3.79	0.021
Pre-frontal	Premotor	L	351	−39	14	54	4.79	0.042
	mPFC/ACC	R	42	3	48	3	4.20	0.014
	IFG	L	160	−50	15	21	4.43	0.003
Striatum	Caudate head	L	409	−12	10	−2	3.82	0.045
EMOTIONAL CONGRUITY
Ant temporal	Ant STS	L	52	−58	−9	−16	3.82	0.039
Insula	Ant insula	R	64	40	14	−14	3.49	0.046
Striatum	Putamen	L	709	−24	−2	3	4.07	0.017
	Caudate head	L		−15	0	14	4.07	0.018
PERCEPTUAL SIMILARITY CONTROL
Pre-frontal	IFG	L	24	−54	34	−2	3.73	0.029
AUDITORY SCENE CONTROL
Parieto-temporal	PCC	L	105	−10	−58	22	4.44	0.004
		R	99	2	−33	44	4.03	0.024
	Post STS	L	21	−66	−44	4	3.86	0.039
Pre-frontal	SMA	L	182	−3	−3	64	4.85	0.034
SEMANTIC CONTROL (SOUND IDENTIFICATION)
Pre-frontal	IFG	L	29	−50	15	21	3.61	0.047

The Table shows grey matter associations of performance on experimental tasks for the combined patient cohort, identified using voxel-based morphometry. All local maxima exceeding significance threshold p < 0.05 after family-wise error correction for multiple voxel-wise comparisons, either over the whole brain (italics) or within pre-specified anatomical regions of interest (Supplementary Fig. S1) in clusters > 20 voxels in size are presented. Peak (local maxima) coordinates are in MNI standard space. Only positive grey matter associations are shown; no negative (inverse) associations were identified at the prescribed significance threshold. ACC, Anterior cingulate cortex; Ant, anterior; IFG, inferior frontal gyrus; L, left; mPFC, medial prefrontal cortex; PCC, posterior cingulate cortex; Post, posterior; R, right; SMA, Supplementary motor area; SMG, supramarginal gyrus; STG/STS, superior temporal gyrus/sulcus. See Section 2.2 for further details of experimental contrasts.